反应详情

温度

80 °C

2-Bromo-6-fluorobenzoic acid (1, 12.50 g, 57 mmol) was dissolved in a mixture of methanol (60 mL) and conc. sulfuric acid (65 mL). The solution was heated to 80° C. and stirred for 12 h. The reaction mixture was cooled and 20% sodium carbonate solution (500 mL) was added slowly to reach pH=8. The mixture was extracted with dichloromethane (3×180 mL), and the combined organic layers were dried over magnesium sulfate and evaporated. The title compound (11.29 g, 48.5 mmol, 85%) was obtained as a brown oil.

1. temperatureThe reaction mixture was cooled
2. extractionThe mixture was extracted with dichloromethane (3×180 mL)
3. dry with materialthe combined organic layers were dried over magnesium sulfate
4. customevaporated