Ammonia → HCID 58495614, compound

Participants

Reaction Steps

To a slurry of Raney Nickel (0.5 g, 50% in water) in ethanol (100 mL) add a solution of 6-[(2,2-dimethylpropyl)thiomethyl]-pyridine-3-carbonitrile (1 g) in ethanol (10 mL) followed by aqueous ammonia (0.88 M, 5 mL) and hydrogenate the mixture in a Parr shaker at 60 psi for 3 h. Filter the mixture through Celite® washing the filter cake with ethanol (50 mL). Remove the solvent in vacuo to obtain the title compound as a colourless oil (1.07 g, 100%).

Provenance & Evidence