Hydrochloric Acid → HCID 58495481, compound

Participants

Reaction Steps

Dissolve 6-(3,3-dimethyl-cyclohexyloxy)-pyridine-3-carbonitrile (9.14 g, 39.7 mmoles) in THF (20 mL) at 0° C. under nitrogen and add borane-THF complex (119 mL, 119 mmol, 1M solution in THF). Stir the resulting solution overnight while warming to room temperature. Slowly add the reaction mixture to a mixture of 5N aqueous HCl (100 mL) and THF (50 mL) at 0° C. and stir for 2 h. Concentrate in vacuo and take-up the residue in a minimum amount of methanol for filtration through a SCX-2 column (10 g) eluting with methanol followed by 3N ammonia in methanol to obtain the desired intermediate as an oil (5.85 g, 63%). MS (ES+) m/z: 207 (M+H)+.

Provenance & Evidence