Sodium Hydroxide → HCID 58495484, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, add lithium aluminum hydride (264 mg, 6.95 mmol) to THF (15 mL) at 0° C. Add a solution of 5-(3,3-dimethylcyclohexyloxy)-pyridine-2-carbonitrile (0.4 g, 1.74 mmol) in THF (5 mL), stir at 0° C. for 1 h and warm to room temperature overnight. Cool the mixture at 0° C. and carefully add water (0.3 mL). Add diethyl ether (25 mL), 3N aqueous NaOH (0.3 mL) and water (0.9 mL), and stir for 1 h at room temperature. Filter the solid residue and concentrate the filtrate in vacuo to obtain the title compound as a colorless oil (360 mg, 88%). MS (APCI+) m/z: 235 (M+H)+.

Provenance & Evidence