HCID 58495644, compound → HCID 58495654, compound

Participants

Reaction Steps

Add 5-cyclohexylethynyl-pyridine-2-carbonitrile (1.4 g, 4.16 mmol) and Lindlar's Catalyst (0.5 g) to EtOAc (20 mL). Bubble hydrogen (via balloon) through the mixture for 2 h and stir under static atmosphere of hydrogen overnight. Filter the catalyst through Celite® and concentrate the filtrate in vacuo. Purify by chromatography on silica gel (80 g, pre-packed cartridge) eluting with hexane/EtOAc (1:0 to 9:1 gradient over 1.25 h, 80 mL/min) to obtain the desired intermediate as a colorless oil (0.89 g, 80%). MS (APCI+) m/z: 213 (M+H)+.

Provenance & Evidence