HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(iso-Propylcarbamoyl-methyl)-benzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | N-(tert-Butoxycarbonyl)-4-(iso-propylcarbamoyl-methyl)-benzylamine | HCID 58495494 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(iso-Propylcarbamoyl-methyl)-benzylamine | HCID 58495524 | 98% |
Reaction Steps
Dissolve N-(tert-butoxycarbonyl)-4-(iso-propylcarbamoyl-methyl)-benzylamine (426 mg, 1.4 mmol) in DCM (5 mL). Add 4M hydrogen chloride in dioxane (3.5 mL, 14 mmol) and stir at room temperature for 1 h. Concentrate in vacuo and elute the compound through a SCX column to obtain the title compound as a white solid (281 mg, 98%). MS (ES+) m/z: 207 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680091B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-016f8e5b4377489ca6e1ffd11c40d576 |
| Source note | uspto-grants-2014_03 |