HCID 59828906, compound → HCID 59828870, compound

Participants

Reaction Steps

Bubble nitrogen into a solution of 4-[2-(2,2-dimethylpropyl-carbamoyl)-ethyl]-benzonitrile (740 mg, 3.0 mmol) in methanol (60 mL) with 3 drops of concentrated HCl for 10 min. Add 10% Pd/C (Degussa type E101, 148 mg) and submit the mixture to hydrogenation at atmospheric pressure overnight. Filter the catalyst over Celite® and concentrate the filtrate in vacuo. Elute the compound through a SCX column to obtain the title compound (717 mg, 95%). MS (ES+) m/z: 249 (M+H)+.

Provenance & Evidence