Water → HCID 58495697, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 4-cyclohexylthio-benzonitrile (1.17 g, 5.4 mmol) in acetone (10 mL) and add water until the sulfide starts to come out of solution. Then add a drop of acetone to rehomogenize the solution. Cool the mixture to 0° C. and then add oxone (4.2 g, 6.73 mmol) in one portion while stirring vigorously at 0° C. for h. Concentrate in vacuo, take up the residue in DCM and filter the suspension through a frit. Concentrate in vacuo to obtain the desired intermediate (1.27 g, 94%) as a white solid.

Provenance & Evidence