Hydrochloric Acid → HCID 58495504, compound

Participants

Reaction Steps

Dissolve 4-cyclohexanesulfonyl-benzonitrile (1.27 g, 5.1 mmol) in anhydrous THF (15 mL) at 0° C. under nitrogen and then add a solution of borane-THF complex (15.3 mL, 15.3 mL, 1M solution in THF). Stir overnight while warming to room temperature. Add the reaction to a mixture of 5N aqueous HCl (50 mL), THF (50 mL) and ice and stir for 1 hour. Concentrate the mixture in vacuo and take up the resulting white residue through a SCX-2 column eluting with methanol followed by 3N ammonia in methanol to obtain the title compound as a white solid (625 mg, 50%). MS (ES+) m/z: 254.1 (M+H)+

Provenance & Evidence