HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethylsulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 58495608, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethylsulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 57447747 | — |
| Reactant | HCID 59828901 | HCID 59828901 | — |
| Product | HCID 58495608 | HCID 58495608 | 43.7% |
Reaction Steps
Use a method similar to the General Procedure 1-2 to couple 7-chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine (348 mg, 0.8 mmol) with 4-dimethylcarbamoylthio-benzylamine (345 mg, 1.6 mmol). Purify by chromatography on silica gel eluting with hexane/EtOAc (4:1) to obtain the desired intermediate (170 mg, 43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680091B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-485e9effc9dc46f39939f51da04368ce |
| Source note | uspto-grants-2014_03 |