HCID 59828880, compound → HCID 59828896, compound

Participants

Reaction Steps

Bubble nitrogen into a solution of 6-[(2,2-dimethyl-propylcarbamoyl)-methoxy]-pyridine-3-carbonitrile (320 mg, 1.3 mmol) in methanol (26 mL) with 3 drops of concentrated HCl for 10 min. Add 10% Pd/C (Degussa type E101, 64 mg) and submit the mixture to hydrogenation at atmospheric pressure overnight. Filter the reaction mixture over Celite®, concentrate the filtrate in vacuo and purify by SCX chromatography to obtain the title compound (314 mg, 96%). MS (ES+) m/z: 252 (M+H)+.

Provenance & Evidence