Hydrogen Peroxide → HCID 59828902, compound

Participants

Reaction Steps

Add 30% hydrogen peroxide solution (0.13 mL, 1.1 mmol) to a solution of 4-[1-amino-2-(cyclopropylmethyl-thiocarbamoyl)-vinyl]-benzylamine (150 mg, 0.57 mmol) in methanol (5 mL). Stir the solution for 16 h at room temperature. Quench the reaction with aqueous saturated sodium hydrogensulfite (1 mL). Extract the mixture with EtOAc (2×30 mL), collect the organic layer and concentrate in vacuo. Purify the residue by chromatography on silica gel (4 g) eluting with DCM/ammonia in methanol (97:3) to obtain the title compound as a yellow solid (68 mg, 46%). MS (ES+) m/z: 243.1 (M-NH3+H)+.

Provenance & Evidence