HCID 58495462, compound → HCID 58495574, compound

Participants

Reaction Steps

Bubble nitrogen into a solution of 4-(1-cyclopropylmethyl-1H-pyrazol-3-yl)-benzonitrile (256 mg, 1.15 mmol) in methanol (48 mL) with 5 drops of concentrated hydrochloric acid for 10 min. Add 10% Pd/C (Degussa type, 48 mg) and submit the mixture to hydrogenation at atmospheric pressure overnight. Filter the mixture over Celite® and concentrate in vacuo. Add saturated aqueous NaHCO3 and extract twice with AcOEt. Dry the combined organic extracts over MgSO4, filter and concentrate in vacuo to give the title compound as a yellow oil (207 mg, 80%). MS (ES+) m/z: 228 (M+H)+.

Provenance & Evidence