HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-[4-(Aminomethyl)phenyl]-N-(cyclopropylmethyl)-4-pyrimidinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 58495645 | HCID 58495645 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[4-(Aminomethyl)phenyl]-N-(cyclopropylmethyl)-4-pyrimidinamine | HCID 58495630 | 96.2% |
Reaction Steps
Dissolve 4-[4-(cyclopropylmethyl-amino)-pyrimidin-2-yl]-N-(tert-butoxycarbonyl)-benzylamine (100 mg, 0.28 mmol) in DCM (3 mL) containing trifluoroacetic acid (2 mL). Stir under nitrogen for 3 h. Concentrate in vacuo and purify the crude mixture by SCX chromatography (5 g) to obtain the title compound (68.5 mg, 90%) suitable for use without additional purification. MS (ES+) m/z: 255 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680091B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-4b0b3de746a448b5a31b10ea8207b7bd |
| Source note | uspto-grants-2014_03 |