HCID 58495438, compound → HCID 58495580, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-[2-(2,2,2-trifluoroethylthio)-1,1-(ethylenedioxy)ethyl]-benzonitrile (248 mg, 0.8 mmol) in anhydrous THF (8 mL) under nitrogen, add borane-tetrahydrofurane complex (9.8 mL, 9.8 mmol) and heat at 60° C. for 3 h. Cool to room temperature and quench with methanol dropwise. Concentrate in vacuo and purify by SCX chromatography to obtain the title compound (250 mg, 99%). MS (ES+) m/z: 308 (M+H)+.

Provenance & Evidence