Cesium carbonate → 6-[(6-tert-butylthiomethyl-pyridin-3-ylmethyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Participants

Reaction Conditions

Reaction Steps

Use a method similar to the General Procedure 1-3. Add 3-aminomethyl-6-(tert-butylthio)methyl-pyridine (2.99 g, 14.2 mmol), 7-chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine (5.05 g, 11.9 mmol), tris(dibenzylideneacetone)dipalladium(0) (275 mg, 0.3 mmol), palladium(II) acetate (133 mg, 0.6 mmol), BINAP (560 mg, 0.9 mmol) and cesium carbonate (5.82 g, 17.9 mmol) to toluene (100 mL) under a nitrogen atmosphere. Heat the mixture at 90° C. for 12 h. Cool the mixture to room temperature. Purify by chromatography on silica gel eluting with hexane/EtOAc (100:0 to 85:15 gradient) to obtain 6-[(6-tert-butylthiomethyl-pyridin-3-ylmethyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (4.1 g, 71%). MS (APCI+) m/z: 486 (M+H)+.

Provenance & Evidence