Methanol → HCID 58495446, compound

Participants

Reaction Steps

Dissolve 7-chloro-6-{4-[(N-methyl-iso-propylamino)-methyl]-benzylamino}-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (350 mg, 0.75 mmol) in concentrated NH4OH. (10 mL) and MeOH (10 mL). Stir the reaction mixture overnight. Concentrate the mixture in vacuo. Purify by chromatography on silica gel (45 g) eluting with a gradient of 100% DCM to 1:1 DCM/(chloroform:methanol:concentrated NH4OH 80:18:2) to obtain 7-chloro-6-{4-[(N-methyl-iso-propylamino)-methyl]-benzylamino}-2,3,4,5-tetrahydro-1H-benzo[d]azepine (260 mg, 93%). MS (APCI+) m/z: 372 (M+11)+.

Provenance & Evidence