7-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethylsulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 86624177, compound

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Reaction Steps

Use a method similar to the General Procedure 1-2 to couple 7-chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine (106 mg, 0.251 mmol) and 4-[2-(2,2-dimethyl-propionylamino)-ethyl]-benzylamine (110 mg, 0.427 mmol). Purify the crude mixture by chromatography on silica gel eluting with hexane/EtOAc (6:4) to obtain 7-chloro-6-{4-[2-(2,2-dimethyl-propionylamino)-ethyl]-benzylamino}-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine as a yellow oil (90 mg, 70%). MS (ES+) m/z: 510 (M+H)+.

Provenance & Evidence