Hydrochloric Acid → HCID 58495536, compound

Participants

Reaction Steps

Dissolve 3-(tert-butoxycarbonyl)-7-chloro-6-[4-(3,3-dimethyl-2-oxobutylthio)-benzylamino]-2,3,4,5-tetrahydro-1H-benzo[d]azepine (35 mg, 0.06 mmol) in DCM (0.2 mL). Add 4M hydrogen chloride in dioxane (0.3 mL, 1.3 mmol) and stir at room temperature for 1 h. Concentrate in vacuo and purify by SCX chromatography to obtain the desired intermediate (26 mg, 93%).

Provenance & Evidence