Hydrochloric Acid → HCID 59828839, compound

Participants

Reaction Steps

Dissolve 3-(tert-butoxycarbonyl)-7-chloro-6-{4-[(2,2-dimethyl-propylcarbamoyl)-methylthio]-benzylamino}-2,3,4,5-tetrahydro-1-H-benzo[d]azepine (51 mg, 0.09 mmol) in DCM (0.2 mL). Add 4M hydrogen chloride in dioxane (0.5 mL, 1.8 mmol) and stir at room temperature for 1 h. Concentrate in vacuo and purify by SCX chromatography to obtain the desired intermediate (39 mg, 93%).

Provenance & Evidence