Water → HCID 86634376, compound

Participants

Reaction Conditions

Reaction Steps

1.0 M of a solution (3.15 mL) of Dibal-H in toluene was added dropwise to the compound 13 (440 mg) and toluene (8 mL) with stirring at −78° C. The reaction mixture was stirred at room temperature for 3 hours and then added water at 0° C. Generated salt was removed by filtration with Celite (trade name) and then the filtrate was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and then concentrated. The obtained residue was dissolved in methanol (2 mL) and then sodium borohydride (40 mg) was added into the solution. The reaction solution was stirred at room temperature for 20 minuets, added water and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, concentrated and obtained the title compound (267 mg) having the following physical properties.

Provenance & Evidence