Cyclohexanol → HCID 86634380, compound

Participants

Reaction Steps

The compound 16 (118 mg), cyclohexanol (0.16 mL), aqueous 5N sodium hydroxide solution (0.25 mL) and 1-(2,6-dichloropyrimidin-4-yl)azepan (83.5 mg) were stirred at 120° C. for 6 hours. The reaction solution was purified by silica gel column chromatography (hexane:ethyl acetate=2:1→1:1) to obtain the title compound (71.2 mg) having the following physical properties.

Provenance & Evidence