Cyclohexanone → HCID 86634385, compound

Participants

Reaction Steps

The compound 20 (151 mg), dimethylformamide (3 mL), acetic acid (0.03 mL), cyclohexanone (0.37 mL), anhydrous sodium sulfate (800 mg) and sodium triacetoxyborohydride (765 mg) were stirred at room temperature for 1 day. The reaction solution was added aqueous 2N sodium hydroxide solution and extracted with dichloromethane. The extract was dried over anhydrous magnesium sulfate and then concentrated. The residue was purified by silica gel column chromatography (ethyl acetate:methanol:triethylamine=80:10:1) to obtain the title compound (118 mg) having the following physical properties.

Provenance & Evidence