Hydrochloric Acid → HCID 68913569, compound

Participants

Reaction Steps

Benzyl (2RS,3SR)-3-[(tert-butoxycarbonyl)amino]-2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate (3.08 g), ethanol (30 mL), tetrahydrofuran (8 mL) and aqueous 2N sodium hydroxide solution (4.4 mL) were stirred at room temperature for 4 hours. The reaction solution was neutralized with aqueous 2N hydrochloric acid solution and then concentrated. The residue was added water and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, concentrated and obtained the title compound (3.00 g) having the following physical properties.

Provenance & Evidence