1,3-Propanediamine → HCID 86634386, compound

Participants

Reaction Steps

The compound 25 (784 mg), dimethylformamide (8 mL), propane-1,3-diamine (300 mg), 1-hydroxybenzotriazole (297 mg) and 1,2-dichloroethane (575 mg) were stirred at room temperature for overnight. The reaction solution was added water and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and then concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=66:34→0:100) to obtain the title compound (797 mg) having the following physical properties.

Provenance & Evidence