Dimethylformamide → HCID 68917835, compound

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Reaction Steps

N-[(2RS,3SR)-2-(2-aminoethyl)-1-cyclohexylpiperidin-3-yl]-4-cycloheptylpyrimidin-2-amine (75 mg), dimethylformamide (1 mL), (2-bromoethoxy)(tert-butyl)dimethylsilane (44 μL) and potassium carbonate (52 mg) were stirred at room temperature for overnight. The reaction solution was added aqueous saturated sodium hydrogen carbonate solution and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and then concentrated. The residue was purified by silica gel column chromatography (ethyl acetate:methanol:aqueous ammonia=70:27:3) to obtain the title compound (89 mg) having the following physical properties.

Provenance & Evidence