tert-Butyl methyl ether → HCID 68922468, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[({2-[(2RS,3SR)-3-[(4-azepan-1-ylpyrimidin-2-yl)amino]-1-(tetrahydro-2H-thiopyran-4-yl)piperidin-2-yl]ethyl}amino)carbonyl]piperidine-1-carboxylate (73.5 mg) in dichloromethane (1.5 mL), trifluoroacetic acid (17 μL) and m-chloroperbenzoic acid (40 mg) were added and then stirred at room temperature for 3 hours. The reaction solution was added aqueous sodium thiosulfate solution and excessive tert-butylmethyl ether, extracted with aqueous 2N sodium hydroxide solution and saturated brine and obtained a crude product of the title compound (84 mg). The obtained crude product was purified by silica gel column chromatography (ethyl acetate:methanol:28% aqueous ammonia=1000:10:1→80:20:2) to obtain a more polar compound and a less polar compound of the title compound having the following physical properties.

Provenance & Evidence