Benzyl piperazine-1-carboxylate → HCID 57869401, compound

HRID 1191295Notes

Reaction equation

HRID 1191295 reaction equation
[N:1]1([C:7](OCC2C=CC=CC=2)=O)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[N:17]1([C:24]2[CH:29]=[C:28](Cl)[N:27]=[C:26]([NH:31][C@H:32]3[CH2:36][CH2:35][N:34]([C:37](OC(C)(C)C)=O)[C@@H:33]3[CH2:44][CH2:45]C=O)[N:25]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[N:17]1([C:24]2[CH:29]=[CH:28][N:27]=[C:26]([NH:31][C@H:32]3[CH2:36][CH2:35][N:34]([CH:37]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)[C@@H:33]3[CH2:44][CH2:45][CH2:7][N:1]3[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]3)[N:25]=2)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 643495Benzyl piperazine-1-carboxylateHCID 86634387HCID 86634387, compound

Product 1

HCID 57869401HCID 57869401, compound

Procedure

The same procedure as a series of reactions of Example 21→Example 16→Example 21→Example 20 was carried out, except that benzyl piperazine-1-carboxylate was used in place of the compound 20 and the compound 40 was used in place of cyclohexanone in the process of Example 21, to obtain the title compound (1.13 g) having the following physical properties.

Sources & evidence

ORD record
ord-e3a4f0ee73a54956a4e4f3347832cc50
Source dataset
uspto-grants-2014_03
Patent number
US08680092B2

Reaction notes

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