反应详情

To a solution of 3-[hydroxy(1-nitronaphthalen-2-yl)methyl]benzonitrile (7.37 g, 24.2 mmol) in dichloromethane (70 mL) was added silica gel (30 g) and pyridinium dichromate (13.7 g, 36.3 mmol), and stirred for 18 hours. The reaction mixture was filtered, and the residue was washed with chloroform. The filtrate was concentrated to dryness, and the residue was recrystallized from ethyl acetate, and washed with hexane to give the titled compound as a pale yellow crystal (6.32 g, yield 86%).

1. filtrationThe reaction mixture was filtered
2. washthe residue was washed with chloroform
3. concentrationThe filtrate was concentrated to dryness
4. customthe residue was recrystallized from ethyl acetate
5. washwashed with hexane