Boron tribromide → HCID 56651008, compound

Participants

Reaction Steps

To an ice-cold suspension of 4-(3-methoxyphenyl)-1H-benzo[h]quinazolin-2-one (120 mg, 0.397 mmol) in dichloromethane (2 mL) was added 1M boron tribromide in dichloromethane (400 μL, 0.400 mmol). The mixture was stirred at room temperature for 18 hours. The resultant mixture was poured into a saturated aqueous sodium bicarbonate solution. The precipitated solid was collected by filtration, purified by silica gel column chromatography (chloroform/methanol=97/3), and recrystallized from DMF/methanol to give the titled compound as a yellow crystal (41 mg, yield 36%).

Provenance & Evidence