Hydrochloric Acid → HCID 66856287, compound

Participants

Reaction Steps

Methyl 5-bromo-2-[(4-methoxybenzyl)(thiophen-2-ylacetyl)amino]benzoate (2.7 g, 5.7 mmol) was taken into tetrahydrofuran (0.50 M, 11 mL) and to this solution was added potassium tert-butoxide (1.3 g, 11 mmol) at room temp. The reaction was stirred for an hour. The crude reaction mixture was poured into 1 N HCl aq. (100 mL). The product was extracted with ethyl acetate (3×50 mL). The combined organic extractions were dried over magnesium sulfate, filtered, and concentrated in vacuo to yield 6-bromo-4-hydroxy-1-(4-methoxybenzyl)-3-(thiophen-2-yl)quinolin-2(1H)-one as a brown oil. Used without further purification. LCMS (M+H)=441.6.

Provenance & Evidence