Dichloromethane → 4-{3-[(4-{[5-Chloro-7-(3-methoxyprop-1-yn-1-yl)-1,3-benzodioxol-4-yl]amino}-6-methoxyquinazolin-7-yl)oxy]propyl}piperazin-2-one
Reaction equation
[CH3:41][O:42][CH2:43][CH2:44][OH:45].[Cl:1][c:2]1[c:3]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][c:23]([O:29][CH2:30][CH2:31][CH2:32][Cl:33])[c:24]([O:27][CH3:28])[cH:25][c:26]23)[c:4]2[c:5]([c:9]([C:11]#[C:12][CH2:13][O:14][CH3:15])[cH:10]1)[O:6][CH2:7][O:8]2.[Cl:46][CH2:47][Cl:48].[NH:34]1[C:35](=[O:40])[CH2:36][NH:37][CH2:38][CH2:39]1>>[Cl:1][c:2]1[c:3]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][c:23]([O:29][CH2:30][CH2:31][CH2:32][N:37]4[CH2:36][C:35](=[O:40])[NH:34][CH2:39][CH2:38]4)[c:24]([O:27][CH3:28])[cH:25][c:26]23)[c:4]2[c:5]([c:9]([C:11]#[C:12][CH2:13][O:14][CH3:15])[cH:10]1)[O:6][CH2:7][O:8]2Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-ee8e5e9082c24a409a39aedd51831740
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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