HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1191343Generated: November 2, 2026
Cesium carbonate → (R)-4-(3-Hydroxy-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one
https://huagongshe.com/reaction/1191343
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2H-1,4-benzoxazin-3(4H)-one | HCID 72757 | — |
| Reactant | (S)-(+)-3-Bromo-2-methyl-1-propanol | HCID 10986449 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (R)-4-(3-Hydroxy-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one | HCID 68910321 | 147.7% |
Reaction Steps
A 25 mL flask was charged with 4H-benzo[1,4]oxazin-3-one (0.100 g, 0.670 mmol), (S)-3-bromo-2-methylpropanol (0.103 g, 0.670 mmol) and cesium carbonate (0.208 g, 0.670 mmol) in MeCN (10 mL) and stirred at 40° C. for 2 days. The reaction mixture was quenched with water (5 mL), and the product extracted into EtOAc (2×10 mL). The combined organic layers were dried (Na2SO4) and evaporated to give the crude title compound (108LM40-37) (0.219 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08680115B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-76876fdfdf8b4405870a63428f13e8c5 |
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| Source note | uspto-grants-2014_03 |
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