HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → (R)-4-(3-Iodo-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | (R)-4-(3-Hydroxy-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one | HCID 68910321 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (R)-4-(3-Iodo-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one | HCID 68908541 | 20% |
Reaction Steps
Crude (R)-4-(3-hydroxy-2-methylpropyl]-4H-benzo[1,4]oxazin-3-one (108LM40-37) (1.040 g), triphenylphosphine (0.99 g, 3.77 mmol), imidazole (0.32 g, 4.71 mmol) and iodine (1.43 g, 5.65 mmol) in CHCl3 (30 mL) were reacted according to GP4 to give the crude title compound (108LM46-43) (0.312 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680115B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-0dda117bf5924278a838368ecf0c502c |
| Source note | uspto-grants-2014_03 |