HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 86600692, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2H-1,4-benzoxazin-3(4H)-one | HCID 72757 | — |
| Reactant | 1-Chloro-3-iodopropane | HCID 81363 | — |
| Product | HCID 86600692 | HCID 86600692 | — |
Reaction Steps
A reaction flask or vial was charged 4H-benzo[1,4]oxazin-3-one (1.0 equiv) dissolved in DMF (0.1 g/ml), Cs2CO3 (1.5 equiv) and 1-chloro-3-iodopropane (1.1 equiv). The reaction was stirred in rt for 60-70 h and evaporated to dryness. The reaction was redissolved in H2O and extracted with EtOAc 3×150 ml. The combined organic phases were dried over Na2SO4 and concentrated to a crude that was used directly or purified by column chromatography (heptanes/EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680115B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-e1fad3e57a0e4a70a03c102430ffa70a |
| Source note | uspto-grants-2014_03 |