Potassium Carbonate → HCID 69671050, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 3-{[2-(2,2-dibromovinyl)-4-ethoxyphenylamino]methyl}benzoate (258 mg), phenylboronic acid (134 mg), tris(dibenzylideneacetone)dipalladium (0) (25.1 mg), tris(2-methylphenyl)phosphine and potassium carbonate (381 mg) in toluene (5 mL) was stirred at 85° C. for 3.5 hours under an argon atmosphere. The reaction mixture was cooled to room temperature, diluted with ethyl acetate and filtered through celite (registered trademark). The filtrate was concentrated under reduced pressure. The residue was purified by aminopropylated silica gel column chromatography (eluting solvent: ethyl acetate-hexane) to obtain the title compound (138 mg).

Provenance & Evidence