2-Aminothiazole → HCID 58869947, compound

Participants

Reaction Steps

The product from Example 1, Part C (350 mg, 1.1 mmol) and 2-aminothiazole (131 mg, 1.3 mmol) were converted to the title compound by the method described in Example 1, Part D (122 mg, 34%). 1H NMR (300 MHz, CDCl3) δ 7.37 (d, J=3.5 Hz, 1H); 7.22 (d, J=8.8 Hz, 2H); 7.02 (d, J=3.6 Hz, 1H); 7.22 (d, J=8.5 Hz, 2H); 5.11 (d, J=14.6 Hz, 1H); 4.61 (s, 1H); 4.17 (d, 14.6 Hz, 1H); 3.76 (s, 3H); 3.06 (s, 2H); 1.93 (s, 3H); 1.79 (s, 3H). MS: m/z (MH+) 404.

Provenance & Evidence