Triethylamine → HCID 58869944, compound

Participants

Reaction Steps

The product from Example 1, Part C (200 mg, 0.6 mmol) was dissolved in 25 mL CH3CN, HOBt (48 mg, 0.3 mmol) was added, and stirring continued for 1 h. 2-Aminopyridine (88 mg, 0.9 mmol), triethylamine (0.18 mL, 1.26 mmol), and HATU (250 mg, 0.66 mmol) were added and the mixture was stirred at room temperature for 2 h. Solvent was evaporated and the title compound was isolated as a white solid by silica gel chromatography (140 mg, 56%). 1H NMR (400 MHz, CDCl3) δ 8.41 (br s, 1H), 8.29 (m, 1H), 8.13 (d, J=8 Hz, 1H), 7.70 (m, 1H), 7.22 (d, J=9 Hz, 2H), 7.06 (m, 1H), 6.83 (d, J=9 Hz, 2H), 5.07 (d, J=15 Hz, 1H), 4.62 (s, 1H), 4.15 (d, J=15 Hz, 1H), 3.77 (s, 3H), 2.90 (m, 2H), 1.95 (s, 3H), 1.84 (s, 3H). MS: m/z (MH+) 398.

Provenance & Evidence