2-Amino-5-cyanopyridine → HCID 67482521, compound

Participants

Reaction Steps

The product from Example 1, Part C (160 mg, 0.5 mmol) and 6-aminonicotinonitrile (89 mg, 0.75 mmol) were reacted as described in Example 5. After evaporation of the reaction solvent the residue was partitioned between water and EtOAc, the aqueous phase was washed with EtOAc. The combined organics were washed with brine, dried (Na2SO4), filtered, and evaporated. The title compound was obtained by silica gel chromatography (30 mg, 14%). 1H NMR (400 MHz, CDCl3) δ 8.84 (br s, 1H), 8.55 (d, J=2 Hz, 1H), 8.30 (d, J=9 Hz, 1H), 7.95 (dd, J=9 Hz, 2 Hz, 1H), 7.21 (d, J=9 Hz, 2H), 6.83 (d, J=9 Hz, 2H), 5.07 (d, J=15 Hz, 1H), 4.63 (s, 1H), 4.12 (d, J=15 Hz, 1H), 3.77 (s, 3H), 2.96 (m, 2H), 1.94 (s, 3H), 1.84 (s, 3H). MS: m/z (MNa+) 445.

Provenance & Evidence