2-Amino-4-methylpyridine → HCID 58869955, compound

Participants

Reaction Steps

The product from Example 1, Part C (0.3 g, 0.93 mmol) and 2-amino-4-picoline (0.151 g, 1.4 mmol) were converted to the title compound by the method described in Part B of Example 16 (0.223 g, 58%). 1H NMR (300 MHz, CDCl3) δ 8.28 (broad s, 1H); 7.92 (d, J=8 Hz, 1H), 7.60 (t, J=7.8 Hz, 1H); 7.23 (d, J=8.6 Hz, 2H); 6.88 (d, J=7.4 Hz, 1H); 6.84 (d, J=8.5 Hz, 2H); 5.11 (d, J=15 Hz, 1H), 4.61 (s, 1H); 4.16 (d, 15 Hz, 1H); 3.76 (s, 3H); 2.89 (s, 2H); 2.44 (s, 3H); 1.94 (s, 3H); 1.84 (s, 3H). MS: m/z (MH+) 412.

Provenance & Evidence