Ethyl bromoacetate → HCID 67482279, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 1, Part B (400 mg, 1.6 mmol) in 15 mL THF was cooled to 0° C. under N2. Sodium hydride (58 mg, 2.4 mmol) was added in two portions and stirring continued for 0.5 h. Ethyl bromoacetate (400 mg, 2.4 mmol) in 5 mL THF was added dropwise over 5 min, and stirring continued at room temperature for 24 h. Solvent was evaporated, the mixture was cooled to 0° C., EtOAc was added, followed by cold water. The aqueous phase was washed with EtOAc. The combined organics were dried (Na2SO4), filtered, and evaporated. The title compound was isolated as an oil and used without further purification (450 mg, 83%).

Provenance & Evidence