2-Amino-5-methylpyridine → HCID 58869954, compound

Participants

Reaction Steps

The product from Example 27, Part B (100 mg, 0.3 mmol) and 5-methylpyridin-2-ylamine (71 mg, 0.66 mmol) were reacted as described in Example 5. After evaporation of the reaction solvent the residue was partitioned between water and EtOAc, and the organic phase was washed with EtOAc. The combined organics were washed with brine, dried (Na2SO4), filtered, and evaporated. The title compound was obtained as a white solid by silica gel chromatography. 1H NMR (300 MHz, CDCl3) δ 8.68 (br s, 1H), 8.14 (s, 1H), 8.07 (d, J=8 Hz, 1H), 7.53 (m, 1H), 7.22 (d, J=9 Hz, 2H), 6.79 (d, J=9 Hz, 2H), 5.16 (s, 1H), 4.75 (d, J=15 Hz, 1H), 4.21 (d, J=15 Hz, 1H), 3.70 (s, 3H), 3.68 (d, J=15 Hz, 1H), 3.58 (d, J=15 Hz, 1H), 2.32 (s, 3H), 1.86 (s, 6H). MS: m/z (MH+) 396.

Provenance & Evidence