Chlorotrimethylsilane → HCID 67482276, compound

HRID 1191715Notes

Reaction equation

HRID 1191715 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][N:3]=1.Cl[Si:12]([CH3:15])([CH3:14])[CH3:13]>N1C=CC=CC=1.C(Cl)Cl>[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([Si:12]([CH3:15])([CH3:14])[CH3:13])=[O:7])=[CH:9][CH:10]=1

Participants

5

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 184966-Aminonicotinic acid

Product 1

HCID 67482276HCID 67482276, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

6-Aminonicotinic acid (86 mg, 0.6 mmol) was taken up in 0.65 mL pyridine and 10 mL CH2Cl2. Chlorotrimethylsilane (0.65 mL, 7 mmol) was added and the mixture stirred for 6 h. Solvent was evaporated and the product was used without purification.

Workup

  1. customSolvent was evaporated
  2. customthe product was used without purification

Sources & evidence

ORD record
ord-bd755fde4ad646be97d0e8c304ddf74f
Source dataset
uspto-grants-2014_03
Patent number
US08680122B2

Reaction notes

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