[2-Bromo-4-(trifluoromethyl)benzyl]malonic acid → 3-(2-Bromo-4-(trifluoromethyl)phenyl)propanoic acid

HRID 1191910Notes

Reaction equation

HRID 1191910 reaction equation
[Br:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[CH2:4][CH:5](C(O)=O)[C:6]([OH:8])=[O:7]>CCOCC>[Br:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

Participants

3

Reactant 1

HCID 22754130[2-Bromo-4-(trifluoromethyl)benzyl]malonic acid

Product 1

HCID 227541293-(2-Bromo-4-(trifluoromethyl)phenyl)propanoic acidYield 85%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

[2-Bromo-4-(trifluoromethyl)benzyl]malonic acid (9.80 g, 28.7 mmol) in a round-bottom flask was heated to 180° C. and heating was continued at 180° C. for 1.5 hrs. After cooling to room temperature, the solid was dissolved in ether. The resulting solution was dried over MgSO4 and concentrated. The solid was washed with hexane to give the title compound (7.20 g, 85%). MS calculated for C10H8BrF3O2: (M+H)+ 297. found 297.0, 299.0.

Workup

  1. temperatureheating
  2. dry with materialThe resulting solution was dried over MgSO4
  3. concentrationconcentrated
  4. washThe solid was washed with hexane

Sources & evidence

ORD record
ord-ba0a46cc6398414bb378d14f4f9c53ef
Source dataset
uspto-grants-2014_03
Patent number
US08680104B2

Reaction notes

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