Sodium Hydroxide → 3-(2-Bromo-5-(trifluoromethyl)phenyl)propanoic acid

HRID 1191922Notes

Reaction equation

HRID 1191922 reaction equation
C([O:3][C:4](=[O:23])[CH:5]([CH2:11][C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:13]=1[Br:22])C(OCC)=O)C.[OH-].[Na+]>C(O)C.O>[Br:22][C:13]1[CH:14]=[CH:15][C:16]([C:18]([F:21])([F:20])[F:19])=[CH:17][C:12]=1[CH2:11][CH2:5][C:4]([OH:23])=[O:3]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 53704455Diethyl [2-bromo-5-(trifluoromethyl)benzyl]malonate

Product 1

HCID 248204723-(2-Bromo-5-(trifluoromethyl)phenyl)propanoic acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

To a solution of diethyl[2-bromo-5-(trifluoromethyl)benzyl]malonate (22.9 g, 57.6 mmol) in ethanol (100 mL) and water (50 mL) was added a 5 M solution of sodium hydroxide in water (30 mL). The mixture was heated to reflux for 2 h. Ethanol was removed by evaporation. The aqueous layer was extracted with ether and then acidified with concentrated HCl to pH 5 at which time a lot of white solid precipitated out. The solid was collected by filtration. The filtrate was extracted with ethyl acetate twice, and the extracts were washed with brine, dried (MgSO4) and concentrated to give a white solid.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 2 h
  3. customEthanol was removed by evaporation
  4. extractionThe aqueous layer was extracted with ether
  5. customprecipitated out
  6. filtrationThe solid was collected by filtration
  7. extractionThe filtrate was extracted with ethyl acetate twice
  8. washthe extracts were washed with brine
  9. dry with materialdried (MgSO4)
  10. concentrationconcentrated
  11. customto give a white solid

Sources & evidence

ORD record
ord-7a1b2f0395e5423d8a0cd82daf0a7c63
Source dataset
uspto-grants-2014_03
Patent number
US08680104B2

Reaction notes

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