HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1191947Generated: November 2, 2026
1-[5-(Trifluoromethyl)-2-vinylphenyl]prop-2-en-1-ol → 6-(trifluoromethyl)-1H-inden-1-ol
https://huagongshe.com/reaction/1191947
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-[5-(Trifluoromethyl)-2-vinylphenyl]prop-2-en-1-ol | HCID 59212656 | — |
| Catalyst | Benzylidenebis(tricyclohexylphosphine)dichlororuthenium | HCID 11967259 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-(trifluoromethyl)-1H-inden-1-ol | HCID 59212623 | 68.8% |
Reaction Steps
To a solution of the 1-[5-(trifluoromethyl)-2-vinylphenyl]prop-2-en-1-ol (462 mg, 2.02 mmol) in methylene chloride (20 mL) under nitrogen was added benzylidene-bis(tricyclohexylphosphine)dichlororuthenium (70 mg, 0.08 mmol). The dark mixture was stirred at 25° C. for 30 min and concentrated. The residue was purified by flash chromatography to give the desired compound (278.1 mg, 68%). LC-MS [M+1]=279.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08680104B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-c516b79e17d54b57be82cae928afd91a |
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| Source note | uspto-grants-2014_03 |
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