HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Iodo-6-methoxy-2-methylbenzo[b]thiophene → 7-Isopropoxy-6-methoxy-2-methylbenzo[b]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Iodo-6-methoxy-2-methylbenzo[b]thiophene | HCID 67287222 | — |
| Reactant | 3-Iodo-7-isopropoxy-6-methoxy-2-methylbenzo[b]thiophene | HCID 67287386 | — |
| Product | 7-Isopropoxy-6-methoxy-2-methylbenzo[b]thiophene | HCID 67286622 | 67% |
Reaction Steps
When 3-iodo-7-isopropoxy-6-methoxy-2-methylbenzo[b]thiophene was substituted for 3-iodo-6-methoxy-2-methylbenzo[b]thiophene in Step C of Comparator D, the identical process provided the title compound in 67% yield, as a heavy colourless syrup. 1H-NMR (CDCl3) 1.33 (d, 6H, J=6.14 Hz); 2.51 (s, 3H); 3.88 (s, 3H); 4.69 (m, 1H, J=6.14 Hz); 6.84 (, 1H); 6.96 (d, 1H, J=8.51 Hz); 7.27 (d, 1H, J=8.51 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680135B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-5aca31aec6da4e738576aa28ad88f022 |
| Source note | uspto-grants-2014_03 |