1-(5-Chloro-4-nitrothiophen-2-yl)ethan-1-one → HCID 46932326, compound

HRID 1192067Notes

Reaction equation

HRID 1192067 reaction equation
Cl[C:2]1[S:6][C:5]([C:7](=[O:9])[CH3:8])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][C:14]=1[SH:23]>>[N+:10]([C:3]1[CH:4]=[C:5]([C:7](=[O:9])[CH3:8])[S:6][C:2]=1[S:23][C:14]1[CH:15]=[N:16][C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:13]=1)([O-:12])=[O:11]

Participants

3

Reactant 2

HCID 5211051-(5-Chloro-4-nitrothiophen-2-yl)ethan-1-oneHCID 178418602HCID 178418602, compound

Product 1

HCID 46932326HCID 46932326, compound

Procedure

Prepared according to the procedure described for example 18 from 1-(5-Chloro-4-nitro-2-thienyl)ethanone (250 mg, 1.215 mmol) and quinoxaline-2-thiol (197 mg, 1.215 mmol). The title compound was obtained as a solid (200 mg, 50% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.26 (1H, s), 8.63 (1H, s), 8.01 (1H, m), 7.98 (1H, m), 2.61 (3H, s). MS m/z: 331.88 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e0f9359f0fd74b66bc34e782091ceebb
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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