4-Phenylbenzylamine → HCID 67495061, compound

HRID 1192095Notes

Reaction equation

HRID 1192095 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[C:21]1([C:27]2[CH:34]=[CH:33][C:30]([CH2:31][NH2:32])=[CH:29][CH:28]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:27]1([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:28]=[CH:29][C:30]([CH2:31][NH:32][C:14]([C:12]2[S:13][C:9]([S:8][C:7]3[C:6]([Cl:20])=[CH:5][N:4]=[CH:3][C:2]=3[Cl:1])=[C:10]([N+:17]([O-:19])=[O:18])[CH:11]=2)=[O:16])=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 3449894-PhenylbenzylamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 67495061HCID 67495061, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (100 mg, 0.28 mmol) and 4-phenyl benzylamine (55 mg, 0.32 mmol). The title compound was obtained as a yellow solid (65 mg, 45% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.41 (1H, m), 8.98 (2H, m), 8.49 (1H, s), 7.63 (4H, m), 7.46 (2H, m), 7.35 (3H, m), 7.38 (1H, m), 4.44 (2H, m). MS m/z: 514.03, 516.08 [M+H]+

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2d447645447b466797d49b2bb2085d4b
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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