4-Methylpiperazine-1-ethylamine → HCID 46932611, compound

HRID 1192096Notes

Reaction equation

HRID 1192096 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][N:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][NH2:30])[CH2:24][CH2:23]1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:30][CH2:29][CH2:28][N:25]2[CH2:26][CH2:27][N:22]([CH3:21])[CH2:23][CH2:24]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 702844-Methylpiperazine-1-ethylamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 46932611HCID 46932611, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 2-(4-methylpiperazin-1-yl)ethanamine (16 mg, 0.12 mmol). The title compound was obtained as a solid (13.6 mg, 29% yield). MS m/z: 476.04, 478.04 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d55baec93017489f971142baa117481a
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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